Pharmacokinetics of cefoperazone in full-term and premature neonates

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Pharmacokinetics of cefoperazone in full-term and premature neonates.

The pharmacokinetics of cefoperazone were evaluated in 28 newborn infants who were being treated for sepsis. A dose of 50 mg/kg was administered intravenously on days 0 to 2 in all, with a second dose administered on days 5 to 7 in 14 infants. Cerebrospinal fluid penetration was also studied in seven neonates. The mean peak concentration of cefoperazone in the serum of premature infants less th...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1983

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.23.6.866